Abstract:
This study represents an advancement in the field of composite material engineering,
focusing on the synthesis of composite materials derived from porous hydroxyapatite via surface
modification employing cucurbit[n]urils, which are highly promising macrocyclic compounds. The
surface modification procedure entailed the application of cucurbit[n]urils in an aqueous medium
onto the hydroxyapatite surface. A comprehensive characterization of the resulting materials was
undertaken, employing analytical techniques including infrared (IR) spectroscopy and scanning
electron microscopy (SEM). Subsequently, the materials were subjected to rigorous evaluation for their
hemolytic effect, anti-inflammatory properties, and cytotoxicity. Remarkably, the findings revealed a
notable absence of typical hemolytic effects in materials incorporating surface-bound cucurbit[n]urils.
This observation underscores the potential of these modified materials as biocompatible alternatives.
Notably, this discovery presents a promising avenue for the fabrication of resilient and efficient
biocomposites, offering a viable alternative to conventional approaches. Furthermore, these findings
hint at the prospect of employing supramolecular strategies involving encapsulated cucurbit[n]urils
in analogous processes. This suggests a novel direction for further research, potentially unlocking
new frontiers in material engineering through the exploitation of supramolecular interactions.
