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Biological relevance of a stable biochemical interaction between the tombusvirus-encoded P19 and short interfering RNAs

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dc.contributor.author Rustem Omarov
dc.contributor.author Kim Sparks
dc.contributor.author Lindsay Smith
dc.contributor.author Jelena Zindovic
dc.contributor.author Herman B Scholthof
dc.date.accessioned 2012-06-28T19:32:35Z
dc.date.available 2012-06-28T19:32:35Z
dc.date.issued 2012-06-29
dc.identifier.uri http://dspace.enu.kz/handle/data/863
dc.description.abstract The Tomato bushy stunt virus (TBSV)-encoded p19 protein (P19) is widely used as a robust tool to suppress RNA interference (RNAi) in various model organisms. P19 dimers appropriate 21-nucleotide (nt) duplex short interfering RNAs (siRNAs) generated by Dicer presumably to prevent programming of the RNA-induced silencing complex (RISC). In the context of virus infection, this model predicts that P19 mutants compromised for siRNA binding cannot prevent RISC-mediated degradation of TBSV RNA and thus reduce viral . en_US
dc.language.iso en en_US
dc.subject Tomato bushy, RISC-mediated degradation, RNA, Dicer presumably en_US
dc.title Biological relevance of a stable biochemical interaction between the tombusvirus-encoded P19 and short interfering RNAs en_US


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