DILACTONE FORMATION BY CHROMIC ANHYDRIDE OXIDATION OF THE GERMACRANOLIDE STIZOLICIN

Abstract

The sidechain of the germacranolide stizolicin was oxidized by CrO3 in Py to form a lactone. The structure of the product was established as 4,5α-epoxy-7α,5,6,8β(H)-germacr-1(10),11(13)-dien-8α(3′-oxo-2′,5′-dihydrofuran-3′-carboxylyl)-12,6-olide using spectral data.